Cushen et al., 2012 Cushen, M., Kerry, J., Morris, M., Cruz-Romero, M., Cummins, E., Nanotechnologies in the food industry - Recent developments, risks and regulation. A., Nanoencapsulation of bovine lactoferrin for food and biopharmaceutical applications. The solution interacts with the antisolvent, increasing the diffusion in the organic antisolvent mixture and causing the precipitation of the solute.Īmong its applications, we highlight the development of biomedical materials based on prolonged liberation mechanisms, such as nanoencapsulation applied to vaccine production, allergy and even cancer treatment, e.g. An organic solution of solvent/solute and the CO 2 enter continuously through a coaxial capillary into a pressurized precipitation chamber pre-charged with antisolvent (CO 2). A., Nanoscale materials development - a food industry perspective. Sanguansri and Augustin, 2006 Sanguansri, P., Augustin, M. J., Co-precipitation of carotenoids and bio-polymers with the supercritical anti-solvent process. This technique generally makes use of CO 2 and allows the processing of a large variety of high quality industrial products ( Martín et al., 2007 Martín, A., Mattea, F., Gutiérrez, L., Miguel, F., Cocero, M. The SAS technique, which is the object of this study, is used as an alternative when the solute of interest is not soluble in the SCF and such technique requires that the organic solvent possess a greater affinity for the antisolvent than for the solute. They are characterized by a pre-expansion chamber where the mixture of solute and the SCF are pressurized and then expanded through a convergent-divergent nozzle causing a sudden pressure drop and the precipitation of the solute. In the RESS techniques, the solute must be soluble in the supercritical fluid (SCF). Martín et al., 2007 Martín, A., Mattea, F., Gutiérrez, L., Miguel, F., Cocero, M. Supercritical Fluid Technology for Drug Product Development: Informa Healthcare (2004). Jerzy et al., 2004 Jerzy Boris, S., Marek, H., Baldyga, Fluid Dynamics, Mass Transfer, and Particle Formation in Fluids. B., Mixing effects on particle formation in supercritical fluids. Techniques for the production of micro- and nanoparticles using supercritical fluids (SCF) have been modified and explored towards diverse applications, including the pharmaceutical, cosmetics, and food industries as alternatives to traditional fine powder production.Īmong such techniques, one can highlight: the RESS - Rapid Expansion of Supercritical Solutions technique and its variants such as RESOLV, RESSAS (Türk and Bolten, 2010), and the SAS technique (Supercritical Antisolvent) and some variants such as SEDS, GAS and PCA ( Bałdyga et al., 2010 Bałdyga, J., Kubicki, D., Shekunov, B. The supercritical state of a mixture is obtained when its temperature and pressure are above their critical values. Supercritical Antisolvent Nanoparticles Mathematical modeling Intensity of segregation CFD Hence, the model resulted in a versatile tool for selecting conditions that may promote a better control over the performance of the SAS process. This corroborates experimental observations from the literature, related to smaller diameters of particles under higher pressures. From analyses of the intensity of segregation, there is an enhancement of the mixture on the molecular scale when the system is operated at higher pressure. For the conditions analyzed, to account for the heat of mixture in the energy balance, subtle variations in the temperature fields were observed, with almost negligible pressure drop. This work presents a numerical study concerning the impact of operating temperature and pressure upon the physical properties and mixture dynamics within the SAS process, because in supercritical conditions the radius of the droplets formed exhibits great sensitivity to these variables. The knowledge of fluid dynamics behavior plays a key role in the search for such parameter combinations. However, a suitable combination of operating parameters is needed for each type of solute. The Supercritical Antisolvent (SAS) technique allows for the precipitation of drugs and biopolymers in nanometer size in a wide range of industrial applications, while guaranteeing the physical and chemical integrity of such materials.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |